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PT364 – Burning Man, Psychedelic Maturity, and Radical Hope

In this episode, David interviews Jamie Wheal: author of the global bestseller, Stealing Fire: How Silicon Valley, Navy SEALs, and Maverick Scientists Are Revolutionizing the Way We Live and Work, and most recently, Recapture the Rapture: Rethinking God, Sex and Death In a World That’s Lost Its Mind.

Wheal believes that in our current culture, we’ve over-fetishized our feelings and jumped too often at selfish psychedelic insights and short-term novelty instead of real long-term growth and maturity – that one’s constant search for freedom can become a prison in itself. As such, he founded the Flow Genome Project, an organization dedicated to human performance research and training, with a different attitude than we’re used to seeing: in their words, “ecstasis without the crave,” “catharsis without the cringe,” and “communitas without the cults.” 

He discusses Burning Man and what makes it so life-changing for people; the sliding scale of psychedelics and the need to regularly do a hard reset of our brains; neuroplasticity; his issues with virtual reality; what Hanukkah has to do with psychedelics; eschatothesia; permaculture and sustainability; and radical hope- the belief in an unknown future that one commits to nonetheless, even in the face of certain doom.

Notable Quotes

“Burning Man is, I think, arguably the most potent transformation engine ever assembled on this planet. I don’t think at any point in history have you ever had that many people – 70 to 80 thousand humans – gathered together at one time, all so concretely and coherently in a mind-blown and open state.”

“The relentless pursuit of freedom becomes a prison house of its own. So you’re not free; you’re actually incapable of committing to anything of lasting value, and therefore, because you have nothing of lasting value to ballast yourself or to justify sacrificing or trade offs, you’re forever seeking the new and the novel. And that just becomes a hamster wheel straight into the Hell realms. So I would say that the freedom of no escape, the freedom of finding your hill to die, the place to take your stand is a non-negotiable part of manhood.”

“Most of us are seeking fucking sugar high joy: distractions, diversions, novelties, quick fixes. And that’s the wrong kind of joy. That is not going to work. But deep, true, abiding joy – ‘We’re all dead men walking,’ ‘Today is a good day to die,’ [attitude], like Leonidas and Thermopylae …It’s that level of out-of-fucks, non-bargaining commitment that gets us access to the joy on the other side of all the facts.”

Links

Recapturetherapture.com

Flowgenomeproject.com

Jamie Wheal substack

Burningman.org: Researchers Share First Findings on Burners’ Transformative Experiences

Nature.com: Prosocial correlates of transformative experiences at secular multi-day mass gatherings

Psychedelics Today: Erik Davis – High Weirdness: Drugs, Esoterica, and Visionary Experience in the Seventies

The Master Switch: The Rise and Fall of Information Empires, by Tim Wu

Wikipedia.org: Eschatology

Radical Hope: Ethics in the Face of Cultural Devastation, by Jonathan Lear

Goodreads.com: Talmud “Do not be daunted by the enormity…” quote

Psychedelics Today: Wade Davis – Ayahuasca and a New Hope for Colombia

IMDB.com: “The Biggest Little Farm”

Gaviotas: A Village to Reinvent the World, by Alan Weisman

Wendell Berry’s “Be joyful though you have considered all the facts” quote


PT363 – Cannabis and Psilocybin: The Complications of Legality Inside an Endless Drug War

In this episode, Joe interviews Reggie Harris: Advisory Board member of Decriminalize Nature and Founder of Oakland Hyphae, which organizes events like the Hyphae Cup (previously the Psilocybin Cup), and performs psilocybin potency testing through Hyphae Labs. 

As Harris is an activist with over a decade of political campaign experience and over a decade in the cannabis industry, this conversation focuses largely on his concerns over the burgeoning psychedelic industry not learning from the mistakes of a failing (at least in California) cannabis industry, as well as one of the key principles of Psychedelics Today: the need to end the drug war immediately and allow the people who got us here to once again live their lives freely. 

He discusses mycology, what a hypha is, and psilocybin potency; how an Eminem song changed his life; why he thinks Oregon is legalizing psilocybin much too quickly; why he thinks we should decriminalize now (and legalize later); the overbearing burden of cannabis industry taxes and how legacy operators are switching to psilocybin; the stories of Kole and Seth Rosenberg; why Mike Tyson is one of the most important influencers in psychedelics; and why “Fuck around and find out” has become a bit of a personal mantra for him and so many others looking to advance our quickly evolving psychedelic space.

Notable Quotes

“I think [that] all we’ve got to do is catch the right politician with drugs, and then the right political parties will start hollering: ‘End the DEA!’ I’m waiting on it. I never thought I’d hear these people start saying ‘Defund the FBI,’ so I think there’s hope.”

“I’d much rather try to hold the wall for a year or two or even five more years and give legacy operators a chance to get their business together, to get their paperwork together, to save up some money, to get their infrastructure together; so that when the wall does come down, they’ve either built something that somebody can buy for a fair price, or they can actually compete. I just want to give people like myself a fair shot at something that they’ve all helped build.”

“I watched a lot of the cultivation decisions being made and crafted and I watched who was making the decisions. I think Oregon is going to be a cautionary tale that the rest of the country uses, again, as to why you don’t want to legalize quickly.”

“You see prices on the street at an all time low, but you still see the people who try to operate within the legalized framework being crushed by being taxed through the nose. You can’t write anything off, you get taxed through the nose, you can’t really bank [any money], you’ve got to pay extra expense because of the nature of your business, and a lot of people make it hard to stand up. It’s funny – as I watch the cannabis industry; in 2018, when they legalized, everybody wanted to play by the rules. Everybody wanted to comply. And so, they cut a lot of the brokers off that they dealt with [and] a lot of relationships were altered because people wanted to go legal. But then when they tried to play around in the legal space for a year, year and a half, and they realized that they were being taxed into oblivion, people opened that back door right on up.”

Links

Oaklandhyphae510.com

Hyphae Labs

Oakland Hyphae Substack

Reggie Harris Linktree

Rollingstone.com: Can Psychedelics and Capitalism Co-Exist? 3 Things I Learned at the Oakland Psychedelic Conference

Biologydictionary.net: Hyphae

Edibleeastbay.com: Mycologist with a Microscope: Alan Rockefeller

Uproxx.com: William Padilla Brown Wants To Save The Planet With Mushrooms

YouTube: Eminem- My Fault

Cannabisni.com: Breckenridge City Colorado Legalizes Marijuana

Psychedelics Today: PT324 – Amanda Reiman, Ph.D., MSW – Web3, NFTs, Cryptocurrencies, and A Deeper Relationship With Plants

Sacrdgardn.com

Occultsentinel.com: OS ep 49 – Kilindi Iyi – The Mushroom and our trans-human future (Joe’s interview with Kilindi Iy from his first podcast)

People.com: Aaron Rodgers Defends Ayahuasca, Says He May Be ‘Called’ to Take the Psychedelic Again

Psychedelicspotlight.com: Will Smith Comes Out of the Psychedelic Closet

Marijuanamoment.net: Dave Chappelle’s Marijuana And Psychedelics Parties Don’t Concern Local Sheriff

NBA.com: NBA Will Not Randomly Test Players For Marijuana Again This Season

Washingtonpost.com: Law enforcement took more stuff from people than burglars did last year

IMDB.com: We Own The Night

The Cannabis Connection podcast: Dave Hodges- Church of Ambrosia & Zide Door 3/11/2022

Healing-mushrooms.net: Uncle Ben’s Mushroom Tek Guide: Fruiting, Colonization Time & Yield

PT319 – Kole – Activism and Trust: A Cautionary Tale From Someone Who Got Caught

Psychedelics Today: PT351 – Seth Rosenberg – The Trauma In Being Arrested and The Injustice of the Drug War

YouTube: Willy’s World

Psychedelics Today: PT236 – Dr. Carl Hart – Drugs: Honesty, Responsibility, and Logic

Psychedelics Today: PT348 – Steve DeAngelo – Cannabis and Psychedelics: Industry, Consciousness, Justice, and Joy

Edrosenthal.com

Merryjane.com: California Cannabis Growers Are Suing the State Over Legal Loophole for Large Marijuana Farms

Colorado.gov: Natural Medicine Health Act of 2022

Marijuanamoment.net: Colorado Psychedelics Legalization And Psilocybin Therapy Measure Qualifies For November Ballot

Psychedelics Today: Addressing Abuse in Psychedelic Spaces

PT362 – Psychedelic Storytelling: Transforming Out Loud

In this episode, Victoria interviews Cory Firth: Chief Storyteller at the Nikean Foundation, one of the world’s leading charities funding psychedelic research and advancing education.

Rick Doblin has famously said that while the FDA responds to data, it’s stories that most resonate with people, and the current direction of the Nikean Foundation is rooted in that idea – that there is a massive population of “psychedelic seekers” who could likely benefit greatly from the psychedelic experience, but who just need to hear that one special story that inspires them to take the leap towards change. While the efficacy of psychedelics and psychedelic-assisted psychotherapy is proven over and over again in study after study, most people don’t connect with that data – it’s the nuance and human connection in personal stories that cut through the “drugs are bad” media bias, and Firth believes that as more people share their transformational tales – who “transform out loud” – society can really change for the better. 

He discusses the value of storytelling in affecting change on multiple levels; the idea of integration as an ongoing practice; the wisdom gained through trauma; and the trust and vulnerability required to be able to share a powerful story. And to practice what they preach, he and Victoria share their own personal stories of healing with the help of psychedelics. We hope they’re stories that someone out there needs to hear.

The Nikean Foundation is aiming to build the largest collection of transformational stories, and they want to hear yours. You can join in by sharing your story at their website, or by sharing the site with a friend. You can submit now, but they officially launch this storytelling project next week, on October 14 at Horizons NYC, where Victoria, Kyle, and David will be! If you haven’t bought a ticket yet, use code PSYCHEDELICSTODAY-NY-17 at checkout to receive 17% off, and when you’re there, come say hello!

Notable Quotes

“Everybody who gets into psychedelics in a transformational way does so because of a friend or a colleague or someone in their family that tells them a story about how they were able to experience them and find some healing potential. …One of the main ways people get into this is through stories. How can we put a little gasoline on that fire and see how it can evolve?”

“You can’t change someone’s mind unless you show them how you changed yours.”

“My goal, eventually, is to have enough stories where someone who’s seeking something can come to the site and see another story of someone who looks like them, in their position – but in the future, where the potential has been reached. They see the potential in themselves. They see the potential of the transformational mechanisms of psychedelics, and they’ve gone through it, and now they see that it’s possible for them.”

Links

Nikean.org: The Nikean Foundation

Psychedelics Today: PT342 – Spencer Hawkswell – The Right to Psilocybin in Canada: TheraPsil’s Charter Challenge

Tim.blog (Tim Ferriss)

Therapsil.ca

Maps.org: MDMA-Assisted Therapy for PTSD

Integration.maps.org: Psychedelic Integration List- Mental Health Support Practitioners by Location

How to Change Your Mind: What the New Science of Psychedelics Teaches Us about Consciousness, Dying, Addiction, Depression, and Transcendence, by Michael Pollan

Rootstothrive.com

GQ.com: Where the Psychedelic Revolution Is Headed, According to the Guy Who (Arguably) Started It (Rick Doblin’s discussed quote is here)

Therapsil.ca: Psilocybin Therapy Offered Cancer Patient Thomas Hartle More Than He Could Have Asked For

Psychscenehub.com: David Nutt’s Drug Harm Ranking scale.

PT361 – Mycology and Evolutionary Genomics

In this episode, Joe interviews Jason Slot, Ph.D.: Associate Professor of Mycology and Evolutionary Genomics at Ohio State University, and founding member and scientific advisor to the Entheome Foundation, which has the goal of publishing 200+ fungal genomes by 2023 – starting with all the psilocybin-producing species.  

Slot talks about evolutionary genomics and his process: how he looks for interesting gene clusters in the genomes of different fungi to hypothesize what these clusters could be responsible for, how different species interact, and how these genes and species have evolved over time. He discusses the state of mycology in 2022 and the booming interest in functional mushrooms; the regulations around psilocybin and how they all relate to the dispensing of mushrooms; the weirdest things he’s seen in the complicated process of mushroom reproduction; substrate supplementation (with different enzymes, tryptophans, or even DMT); and just how much there still is to discover in the world of mushrooms and other possible plant medicines. 

He also discusses illumina high throughput sequencing; tetrapolar mating systems; Paul Stamets’ P-Value scale and the hayflick limit; mushroom parasexuality; horizontal gene transfer; and a lot of other scientific aspects of the unique studies of a mycologist. If you’re interested in psilocybin-producing mushrooms and want to explore mycology more deeply, this episode serves as a great introduction.

Notable Quotes

“It’s a small field, but I think that it’s growing. I think we have a lot more interest coming in because the growth of gourmet and medicinal mushrooms is just ridiculous. It’s a huge industry in the making.”

“I do crazy evolutionary analyses with all the fungal genomes I can get my hands on, and then find something interesting in the evolutionary history, and then I find an organism that’s got that particular gene or gene cluster that I’m interested in. It gives rise to interesting hypotheses.”

“They’re organisms with their own existences. We tend to think of a mushroom as a tool for therapy, or we think of a mushroom as a product or something like that. But these are organisms with their own rights to exist and thrive as they would.”

Links

Ohio State University: Center for Psychedelic Drug Research & Education

Entheome: The Entheogen Genome Project

Psychedelics Today: Brian Pace and Jason Slot – Neurochemical Ecology, and the Evolution of Psilocybin Mushrooms

Ucdavis.edu: Illumina High Throughput Sequencing

Nanoporetech.com: Nanopore DNA sequencing

Scottsdaleinstitute.org

420dc.com: Penis Envy Mushrooms Review: The Shocking Truth Behind The World’s Most Psychedelic Shroom

Wikipedia.org: Parasexual cycle

Fungi.com (Paul Stamets)

Shroomery.org: Biotransformation of tryptamine derivatives in mycelial cultures of Psilocybe

Wikipedia.org: Horizontal gene transfer

Hostdefense.com: What Is the Stamets P Value® System?

Wikipedia.org: Hayflick limit

Convention on Biological Diversity: About the Nagoya Protocol

PT360 – Kanna: Love and Wholeness Through Nature’s Alternative to MDMA

In this episode, Joe interviews Stephanie Wang: Founder and CEO of KA! Empathogenics, which has created the first-ever empathogenic supplement chew with the primary ingredient of kanna. 

Similar to our exploration of kratom with Oliver Grundmann, Ph.D., this episode dives deep into a plant rarely talked about in psychedelic circles: kanna (or Sceletium tortuosum), a succulent native to South Africa. As a natural serotonin reuptake inhibitor and serotonin releasing agent, kanna’s effects sound very similar to those of MDMA (heart-opening, feeling surrounded by love and wanting to connect, an increase in energy, hunger suppression), but with a lot more: sleep improvement, a decrease in gut inflammation, increased focus and awareness, and a feeling of brain recalibration and true homeostasis (and it’s legal!). KA!’s first product is their kanna chew: a healthy, pH-neutral snack with no sugar, preservatives, caffeine, or artificial sweeteners, made with the intention to “restore full spectrum aliveness for all human beings.” 

Wang breaks down the science behind why kanna works, its history with the Khoisan people of South Africa, her first kanna plant ceremony, contraindications and what pairs well with it, how you should take it and how long it can last, and why she chose KA! as the name for her company. She and Joe also talk about their shared past with Evolver, the complexity in the simple question: “How are you?”, the care needed when making comparisons, society’s move towards self-directed healing and more natural foods, and the question of whether or not every modern culture is truly ready for psychedelics and natural plant medicines.

Notable Quotes

“It was amazing to experience kanna in a ceremonial setting where it was incredibly expansive and heart-opening. That’s literally how it feels: You just feel this oneness and you feel enormous love. You feel everything around you is love, everyone is love. And what it also had an effect on is how we were relating to each other in that setting. So imagine that you’re in a place where nothing matters. Nobody cares what you look like, where you came from, what job you have, how much money you make, what social strata [you’re in]; nobody cares. All you care about is meeting each other in that heart-centered space, in a very human and intimate space.”

“One out of five Americans (at least) suffer from some kind of mental health issue. …[Something] you talk about a lot in your show is this wholeness: we are far more than just our minds. We are bodies, we are hearts, we are spirit as well. So really looking at that as a whole is tremendously important, and kanna is one of those amazing plants that starts to connect you to that understanding.”

“What we look for a lot, in terms of our own healing, is in nature already. And instead of trying to tease out, ‘Okay, here’s the active component and let’s just isolate this, patent this, etc. and then make a drug, and then…’ – that’s, to me, an old model, actually. And what happens is then… the wholeness is lost. …There’s a reason why this particular plant evolved this way and has all these properties.”

Links

Ohmyka.com (KA Empathogenics)

Evolverhealth.com

Thealchemistskitchen.com

Realitysandwich.com

Facebook: Evolver Boston (for a piece of Joe’s history)

Wikipedia.org: Khoisan people

Iamshaman.com: Lost Khoisan Tribe (and kanna usage)

5rhythms.com

Psychedelics Today: The Intertwined Prohibitionist Histories of Psychedelics and Kratom

Vice.com: This Legal Supplement Made Me Roll Like I’d Taken MDMA

NIDA: What are MDMA’s effects on the brain?

Biorxiv.org: Revised estimates for the number of human and bacteria cells in the body

Electricalclassroom.com: What is kA rating?

Trailblazerspresents.com

PT359 – Art, Philosophy, Sexuality, and “Psychedelics Tonight”

In this episode, Joe interviews Sawyer Hurwitz: filmmaker, producer, editor, and augmented reality collage artist who releases animated art under the name, “Psychotronic Solutions.”

He is also the director and lead editor of something we’re quite proud of here at Psychedelics Today: our new TV show, “Psychedelics Tonight”; a series of 30-minute episodes hosted by Joe and Kyle exploring lesser-explored psychedelic compounds, presented through ALTRD.TV. Episode 1, “Investigating Iboga – The African Plant with Sacred Roots,” premiered last night, and a new episode will air each Monday through October at 6 p.m. PST. Since this podcast was recorded while the show was still being filmed, they don’t go into it much, but we will be having more in-depth discussion after season 1 finishes, and want to know what you think! To watch for free, click the link in our bio or head to ALTRD.TV and search for Psychedelics Tonight. 

Hurwitz discusses his past of feeling almost addicted to LSD exploration; his art and how LSD helped him overcome the classic artist’s restrictive “I’m not good enough” paradigm; Sarajoy Marsh’s Trauma-informed, Brain-sensitive Yoga being used in prisons to essentially create wellness communities; psychedelics and creativity; Nietzsche’s notion of Apollonian and Dionysian forces; entropy and negentropy; the relationship between psychological unwinding and sexuality and his realization (during a psychedelic experience) that he was queer; and how artists can differentiate themselves in a world where art is more readily available than ever.

Notable Quotes

“[LSD] helped me relinquish the idea that I am creating and that I am anything, and instead, just succumb to the process and engage with the medium in the way that one would a lover. And again, maybe that’s too heady or silly, but just being present with the art is what I think allows it to reach its fullest blossom, and just trusting the fact that I’m doing the best I can.” 

“I think that love on a spectrum and sexuality on a spectrum is so much more chaotic than the firm binary that we’ve put [faith] into for so long. And again, if psychedelics are something that open up your perspectives, it allows you to sort of break models that you’ve been born into and raised with. And for a lot of people, that’s discovering that their experience (wherever it falls on that spectrum) is maybe outside of what we’ve been calling the norm for a long time, as opposed to necessarily what is the norm. I suspect that the norm is that the experience of love and sexuality is so, so, so, so much more diverse than we’ve been characterizing it as for a very long time.” 

“I think that a lot of the drive for art comes from a need to communicate love and connection, and in a lot of ways, that connection is the experience of God. And I think that, in a sense, art comes from almost a divine place in that regard, and psychedelics are also a tool for us experiencing that. Again, I’m not a religious person by any means, but psychedelic experiences are often spiritual experiences, and I think it’s because they touch on the same thing: what it means to live in oneness with the world.” 

Links

Psychedelics Tonight

Psychotronicsolutions.com

Instagram: @psychotronicsolutions

Psychedelics Today: PT311 – William Leonard Pickard – LSD, Fentanyl, Prison, and the Greatest Gift of All: The Natural Mind

Sarahjoyyoga.com: Trauma-informed, brain-sensitive yoga training

Be Here Now, by Ram Dass

The Way of the Psychonaut Vol. 2: Encyclopedia for Inner Journeys, by Stanislav Grof, MD, PhD

YouTube: Let’s Talk: Psychedelics and Queer Identity (a Psychedelics Today webinar)

Epochemagazine.org: Eros and Thanatos: Freud’s two fundamental drives

The Birth of Tragedy and Other Writings, by Friedrich Wilhelm Nietzsche

Wikipedia.org: Negentropy

Alexgrey.com

Allysongrey.com

Androidjones-obtain.com

Amandasage.com

Screenshot from the opening of the animation, “Weird Trip.” Check out the full piece and more at psychotronicsolutions.com.

PT358 – Contexts of Use: Exploring the Various Paradigms of Psychedelics

In this episode, Kyle interviews Clinical Psychologist, past guest, and Founder of the Psychedelic Society of Vermont, Dr. Rick Barnett, Psy.D.

This episode was recorded live in front of a small audience at the Railyard Apothecary in Burlington, VT, shortly after the Psychedelic Science & Spirituality Summit, which Joe and Kyle attended (hosted by Barnett’s Psychedelic Society of Vermont). They reflect a bit on the conference (perhaps the best one Kyle has attended) and Kyle’s history in Vermont, but most of their conversation revolves around exploring  the various contexts of use around psychedelics – how our current paradigm of a heavy focus on medicalization and treatment of disorders misses a huge portion of real-world use: self-improvement, ceremonial, celebratory/recreational, and to even help with addictions. 

They discuss MAPS and MDMA use for PTSD; psilocybin for end-of-life depression and alcohol use disorder; ibogaine for getting off opiates; Chris Bache, high dose LSD sessions, and preparing for death; how dietas are better preparation for an experience than what most studies call for; Jon Dennis’ fight for religious use of psychedelics; decriminalization vs. legalization; how psychedelics helped Barnett connect with the spiritual and communal aspect of 12-step programs; the beauty and pitfalls of celebratory/recreational use; and how there’s really no wrong door when it comes to how one uses psychedelics (as long as it’s safe and respectful).

For regular listeners, this episode may be a bit introductory, but it may also be a great episode to share with your friends who are starting to become interested in this exciting new world. Do you want to attend a live recording and ask the guest questions? Keep an eye on our events page for the next one!

Notable Quotes

“How do we integrate the science that’s happening (the research) with what’s already happening out there in communities? There are people using psychedelics in ceremonial use, [for] celebration, [and] for recreation, and I want to integrate it all, because there’s no wrong door here, I think.”

“That’s a highlight for me: how psychedelics can change our minds; not so much in terms of treating depression or PTSD or addiction, but really challenging us to see ourselves and the world differently, whether we have a psychiatric condition or not.”

“I think we need to embrace all paths, and that’s why I also think decriminalization may not go far enough for some people. That’s an argument out there. I believe in decriminalization, I believe in legalization. Again, there’s no wrong door here. We can medicalize, we can decriminalize, we can legalize, ‘recreationalize,’ buy LSD in Walmart, whatever. I think that having the broadest mind possible and recognizing that there are potential benefits and keeping safety top of mind [is key].”

“I was lucky enough to get really sick from alcohol and wind up in the hospital and eventually wind up in rehab. And I’ve said this publicly before: I don’t think I would have been receptive to the message of recovery in a 12-step based program, which has a lot of spiritually associated with it and there’s a tremendous amount of fellowship and community that comes with 12-step programs. And I had a sense of that because of my LSD use before I got sober. So coming into recovery knowing what I knew, having experienced what I experienced; it was a little bit easier for me to be receptive to that community, that fellowship, that message of spirituality, of surrender, of honesty and openness, willingness – all the principles in a 12-step program.”

Links

ALTRD.tv: Psychedelics Tonight

Drrickbarnett.com

Psychedelics Today: PT326– Dr. Rick Barnett, Psy.D – Addiction, Recovery, and Competency in Psychedelic Therapy

Vermontpsychedelic.org

Psychedelics Today: Kyle and Joe – Contexts of Psychedelic Use

The Psychedelic Renaissance: Reassessing the Role of Psychedelic Drugs in 21st Century Psychiatry and Society, by Dr. Ben Sessa

Awaknlifesciences.com

Psychedelics Today: PT229 – Dr. Matthew Johnson – What is Consciousness?

Usonainstitute.org

Fluencetraining.com

MAPS.org: MDMA-Assisted Therapy for PTSD

Pubmed: Why MDMA therapy for alcohol use disorder? And why now?

Clearmindmedicine.com

Psychedelicsdaily.com: Ibogaine

Psychedelics Today: PT294 – Andrew Tatarsky, Ph.D. & Juliana Mulligan – Vital Psychedelic Conversations (good episode about ibogaine)

Hopkinsmedicine.org: Hallucinogenic Drug Psilocybin Eases Existential Anxiety in People With Life-Threatening Cancer

Imperial.ac.uk: Magic mushroom compound performs as well as antidepressant in small study

Publichealth.jhu.edu: Comorbid Patterns with Alcohol Use Disorders research

NYtimes.com: After Six-Decade Hiatus, Experimental Psychedelic Therapy Returns to the V.A.

Wayofleaf.com: Psychedelics and Eating Disorders

NPR.org: A New Way To Quit? Psychedelic Therapy Offers Promise For Smoking Cessation

Hopkinsmedicine.org: Johns Hopkins Receives Grant for Psilocybin Research in Smoking Cessation

Psychedelics Today: Chris Bache – LSD and the Mind of the Universe: Diamonds from Heaven

LSD and the Mind of the Universe: Diamonds from Heaven, by Christopher M. Bache

Psychedelics Today: PT293 – Stanislav & Brigitte Grof – The Evolution of Breathwork and The Psychology of the Future

LSD: Doorway to the Numinous: The Groundbreaking Psychedelic Research Into Realms of the Human Unconscious, by Stanislav Grof

Marijuanamoment.net: Vermont Governor Vetoes Bill On Safe Drug Consumption Sites And Harm Reduction

Psychedelics Today: Oregon, Measure 109, and Community Access: The Final Vote

Congress.gov: H.R.1308 – Religious Freedom Restoration Act of 1993

The Road to Eleusis: Unveiling the Secret of the Mysteries, by R. Gordon Wasson, Albert Hofmann, and Carl A. P. Ruck

Clinicaltrials.gov: Mescaline

Mescaline: A Global History of the First Psychedelic, by Mike Jay

Dancesafe.org

Breadandpuppet.org

Psychedelicsinrecovery.org

Lucid.news: Bill Wilson, LSD and the Secret Psychedelic History of Alcoholics Anonymous

A picture of Kyle and Dr. Barnett from the live event

PT357 – Precision Psychiatry, Ketabon, and The Stress Response System

In this episode, David interviews drug developer, clinical psychiatrist, and Chief Medical Officer at HMNC Brain Health; Dr. Hans Eriksson. 

Eriksson discusses the complexity of the human brain and his fascination with the ability for simple biological interventions to affect really profound disorders – that while psychotherapy and community can have a major effect, sometimes a simple chemical can fix everything. HMNC Brain Health is currently in Phase 2 trials for Ketabon, a ketamine-esque prolonged-release oral capsule which early studies show does not include any dissociation – something a lot of people do not want. And, as a lot of current medicine is guess work, they have also created a blood test (and are working on other predictive diagnostic tests) to identify specific common markers to show who will most likely respond to specific interventions. This work is firmly rooted in the idea of precision psychiatry, with the theory that there will be far fewer patients with treatment-resistant depression if their physicians are able to see which treatments will actually work for them ahead of time. 

He fully explains the stress response system and Vasopressin system, discussing the likely links between stress response dysfunction and depression; and goes into much more: his thoughts on Compass Pathways’ phase 2 data; the famous Escitalopram vs. psilocybin study; how much of progress can be attributed to psychotherapy vs. the compound itself; why it makes sense to study a new compound on top of SSRIs rather than on its own; AI and machine learning; and how science is truly beginning to come to terms with the fact that all systems in the body are connected.

Notable Quotes

“I was really fascinated by the understanding that on one level, this extremely complex system of the human brain (probably the most complex system in the known universe) can find some of the explanations regarding its functioning in chemicals [and] in compounds of different sorts interacting with targets, receptors, transporters, etc.; and that this can have a profound effect on how we feel and think. And this link between, on one hand, basic biology, and on the other hand, this complex emotional world that is being a human, is so fascinating.”

“If someone comes into the hospital after a car accident and needs a blood transfusion, no one would ever think the thought that: ‘We take any blood we have in storage.’ They would check what blood [type] you have. …But still, in psychiatry, when someone comes in with a severe depression, we hand out an SSRI typically as the first-line treatment. But think: if you could have a tool that could say, ‘Okay, but you belong to the 30% that has a very good likelihood of responding very well to a medicine that corrects your stress response system,’ that could lead to [a] much shorter path from the interaction with the healthcare [provider] to actually overcoming the depression.”

“One area that I expect to be developing quite a lot in [the] coming years is to understand how the brain is affected by things that are ongoing in other parts of our bodies; for instance, things such as peripheral inflammation: Does that affect the brain? The composition of the gut microbiome in our guts: What effect does that have on the brain? I think we are probably moving into an era where we see the brain not only as an isolated world swimming around in the cerebrospinal fluid protected by the blood-brain barrier, but actually as more of a dynamic part in our bodies.”

Links

HMNC-brainhealth.com

Compasspathways.com: COMPASS Pathways announces further positive results from groundbreaking phase IIb trial of investigational COMP360 psilocybin therapy for treatment-resistant depression

NEJM.org: Trial of Psilocybin versus Escitalopram for Depression

Max Planck Institute of Psychiatry

Psychedelics Today: Amanda Feilding – The Beckley Foundation: Changing Minds through Psychedelic Research

Pubs.asahq.org: The Vasopressin System: Physiology and Clinical Strategies

YouTube: Amanda Feilding on Trepanation

Washingtonpost.com: The Google engineer who thinks the company’s AI has come to life

PT356 – Investing in Psychedelics and The Rush to Improve on the Classics

In this episode, Joe interviews Brom Rector: podcaster and founder of Empath Ventures, a venture capital fund that invests in psychedelic medicine startups.

Rector talks about which companies he sees succeeding, which companies are set up to fail, which he is investing in, and why the current crash in psychedelic business (where everything was once over-hyped and now we’re being overly skeptical) is a good thing. He believes that with the current focus on medicalization, the psychedelic community is being ignorant over just how big of an industry will exist outside of that paradigm, and finds it interesting how many people are focused on creating new compounds: How can anyone really improve on the classic psychedelics? 

Other than a focus on the business side of psychedelics, this was recorded in-person, and the conversation goes to a lot of other places: the theory of psychedelics damaging heart valves; the connection between Oprah, MDMA, and Mormons in UTAH; Xanax as a psychedelic security blanket; why so many psychedelic-friendly people love microdosing but have never had a deep experience; logical positivism and why “evidence-based” sounds pretentious; the DSM-5; Colorado Initiative 58; the power in branding and the emergence of high-end packaging; Mike Tyson; Compass Pathways; Christian Angermayer’s leaked memo; ibogaine; Dr. Zee and the next generation of Shulgins, other ways of knowing; and much, much more (just look at how many links there are). 

Notable Quotes

“The tech, future-y, optimist version of me that likes the idea of progress and experimentation at all costs loves it, but it’s also like: mushrooms have been around for like 2,000 years. In business, in order to succeed, you need to improve on something, and usually not just an incremental improvement either – you need to make a big improvement, otherwise no one really cares. Can you imagine what a 10x improvement over psilocybin would be? I can’t really imagine that.”

“You see all these …sketchy Canadian companies, and a lot of them are just making the slightest modifications to these molecules, calling them something new, sending out a bunch of press releases, raising money for investors; and is that – this bullshit thing started by this random company, going to replace psilocybin? I don’t think so.” 

“I’ve heard a lot of different companies talking about trip-stoppers as a big business plan, and I don’t know, dude. It’s interesting; the thing to me (and this is just my personal gut reaction about this) is in my experience, the moments immediately following when I thought I wanted the trip to stop is when I learned the lesson.”

“I think that they may realize eventually that this IP stuff may be helpful for them to achieve dominance in the pharma space, but it’s not going to prevent people from growing their own mushrooms, [or] people from seeking decriminalized care under Measure 109 or [in] Denver. …People are just kind of being willfully ignorant of how big this non-FDA market for psychedelics is going to be, I think. And maybe the people at Atai think that they can stop it by lobbying or something, but I don’t think they think they can do that. The people are going to speak, and the people want shrooms.” 

Links

Empath.vc

Apple podcasts: ”Brom Podcast” (formerly “The Integration Conversation”

Brom Podcast: 35: Sam Banister – The Art and Science of Designing Novel Psychedelic Compounds

Psylo: Psychedelic-inspired medicine to treat mental illness

Thethirdwave.co: Do Psychedelics Carry A Heart Risk?

Dancesafe.org: Is MDMA Neurotoxic?

Prnewswire.com: Numinus to Acquire Novamind, Creating the North American Industry Leader in Psychedelic Therapy and Research

Psychedelicalpha.com: Psychedelic Bulletin: MINDCURE – A Canary in the Psychedelic Coal Mine?

Fieldtriphealth.com

Compasspathways.com

Psychedelics Today: PT233 – JR Rahn of MindMed – LSD, ADHD, and Decriminalization

Psychedelics Today: The Teafaerie – Psychedelic Emergenc(y), Shamanism, 5-MeO-DMT and more!

Huffpost.com: Drugs and the Meaning of Life

Aubreymarcus.com

YouTube: Alex Jones – Magellan is a lot cooler than Justin Bieber

Awaknlifesciences.com

Wikipedia.org: Logical positivism

Leafly.com: Election 2022: Colorado psychedelic legalization and decriminalization guide

Twitter: Zeus’ post (LSD atomizer, not a DMT pen)

Apple Podcasts: Hotboxin With Mike Tyson

Schedule35.co

Psychedelics Today: PT351 – Seth Rosenberg – The Trauma In Being Arrested and The Injustice of the Drug War

Wikipedia.org: Legal status of ibogaine by country

Twitter: Depressed panda meme

Beond.us

YouTube: Linton Kwesi Johnson – Inglan Is a Bitch

How to Change Your Mind: What the New Science of Psychedelics Teaches Us about Consciousness, Dying, Addiction, Depression, and Transcendence, by Michael Pollan

Vice.com: Investors Are Debating Who Should Own the Future of Psychedelics

Wavepaths.com

Psychedelics Today: PTSF 41 (with Mendel Kaelen of Wavepaths)

Nue.life

Kanna.health

Ethnopharmacologic Search for Psychoactive Drugs (Vol. 1 & 2): 50 Years of Research, Edited by Dennis McKenna

The Encyclopedia of Psychoactive Plants: Ethnopharmacology and Its Applications, by Christian Rätsch

Drzee.org

PT355 – The Drug War, Caregiving, and Blue Sky Thinking

In this episode, David interviews Ifetayo Harvey: Social media manager for Caring Across Generations and Founder of the People of Color Psychedelic Collective (POCPC), which educates and builds community for people of color who are interested in psychedelics and ending the drug war.

She talks about her childhood and what it was like to have her father be arrested and sent to jail for selling cannabis; her realization of our history of systemic racism and law enforcement’s disproportionate targeting of Black people; why she wanted to try psychedelics; her first mushroom experience; and her path to MAPS, Drug Policy Alliance, living in New York, putting on a conference; and finally, entering the world of caregiving. 

She discusses how too often race is talked around (instead of about); what we can learn from the pitfalls of legal cannabis and the ongoing opioid crisis; drug war reparations; New York’s cannabis social equity programs; and the importance of centering society around care and caregiving. They talk a lot about “blue sky thinking,” and how a lot of problems exist largely because we’ve grown comfortable in complicity and simply haven’t come together to say: “We want this to change.” 

Notable Quotes

“It was overwhelmingly beautiful, being in nature. And I just felt like I saw a different side of life, a different side of my imagination and my mind. For a long time, I would say all of high school, I identified strongly with atheism. …I grew up around a lot of Christian folks, and spirituality; I knew existed because my mom was spiritual. But I didn’t feel that. When I took mushrooms, I felt that a lot more, and I’m like, ‘Whoa, there’s no denying this.’”

“There was a panel on race and I just remember going there and being really excited, being like ‘Hmm, what are we going to talk about?’ and then leaving feeling really deflated because it seemed like everyone on the panel was too cautious about talking about it. When it came to talking about race, everyone was talking around the issue instead of talking directly to it, and that kind of stuff makes me uncomfortable, because who does it serve to not talk directly about race? And who does it hurt?”

“What I hope happens is that people start to realize we do have a say-so in how things play out. We can come together as people who care, people who have aligned values, and say, ‘We want to organize around this, we want to build power around this.’ …There’s this tendency to just be passive and just say, ‘Oh well, the people with the money are going to do what they want to do and hey, there’s nothing we can do about it.’ …I hope that more people come together and realize that you can have an impact. You can have power in this.”

“In this time that we’re in with COVID, monkeypox, wars happening, climate change; hope feels like a discipline. And that can feel hard at times, but also, it reminds us that we have to work towards something.”

Links

Ifetayo.me

People of Color Psychedelic Collective

Drugpolicy.org

Drugpolicy.org: Children of Incarcerated Parents Bear the Weight of the War on Drugs

Ted Talk: Kimberlé Crenshaw- The urgency of intersectionality

MAPS.org

YouTube: “Dismantling Patriarchy in Psychedelics” panel

Leafly.com: How I got one of NJ’s first 11 cannabis dispensary licenses

NYCLU.org: Stop-and-Frisk Data

NBCnewyork.com: NYC Cops Told to Let People Smoke Weed in Public (Where it’s Allowed)

Thecannabisalliance.us

Caringacross.org

PT354 – Psilocybe, Microdosing, and Multigenerational Mycology

In this episode, Joe interviews Laura Guzmán-Dávalos: 40-year veteran mycologist at the University of Guadalajara, Mexico; and daughter of Gaston Guzman, who most consider the world authority on the genus, Psilocybe. 

Much of Guzmán-Dávalos’ work revolves around collecting and documenting fungal specimens in and around Mexico, with an overarching goal of better understanding the interactions of different mushroom species. Even though many species were discovered in Mexico, the country seems to be a bit behind in terms of documented real-world evidence, so she’s speaking with microdosers to learn more about their habits, while also studying how alkaloids are involved in the effects of psilocybin. Additionally, one of her Ph.D. students is researching the use of mushrooms among different cultures in Oaxaca, and Guzmán-Dávalos believes they will uncover many differences and solid evidence to help lay the groundwork for legalization. 

She talks about ethnomycology and what she does as a mycologist; Psilocybe and psilocybin-containing mushrooms; what basidium is; functional mushrooms and how the mushroom hype has made her life a lot busier; and brings up a good point: With all the discussion about new companies isolating the drug and removing the psychedelic experience, have we considered how similar that concept is to microdosing?

Notable Quotes

“I am excited that normal people are looking to mushrooms because of [the hype around them] …because [there] was a time that they were forgotten. So it’s very good that normal people [are looking at] mushrooms again. But [they need] to be careful that not all mushrooms function or serve for everything.”

On her father, Gaston Guzman: “I am very, very grateful [for] him. I. He introduced me [to] this life, because it’s not work – It’s a life. And I love it.”

Links

Researchgate.net: Laura Guzman-Davalos’s research

Academia.edu: Laura Guzman-Davalos

UDG.mx: UdeG has the most important mycological collection in Western Mexico

Telluride Mushroom Festival Keynote Speaker: Laura Guzman-Davalos

Wikipedia.org: Basidium

Fantasticfungi.com

PT353 – Psychedelics and Creativity

In this episode, Kyle interviews three past guests: author, microdosing enthusiast, and legendary researcher, Dr. James Fadiman; ecologist, researcher, and science writer focusing on psychedelics’ capacity to influence nature connectedness, Dr. Sam Gandy; and professor, writer, researcher, and Co-Founder and Director of Breaking Convention, Dr. David Luke

Gandy and Luke recently co-wrote a paper called “Psychedelics as potential catalysts of scientific creativity and insight,” and Gandy reached out to have us set up a conversation with Fadiman, since he was one of the early voices behind the concept of psychedelics for creativity. And this podcast is that conversation: less of a Kyle-lead interview and more of three people picking Fadiman’s mind. 

He talks about his 1966 paper on creative problem-solving and how his research team established its protocol with real-world experience, and then the three of them discuss much more: the differences between artistic and scientific creativity; how the psychedelic experience is similar to dreaming and the hypnagogic state; microdosing; why Indigenous cultures who say ayahuasca spoke to them are likely accurate; DMT entity encounters and problem-solving; society’s lost interest in divination; pluralistic perspectivism; why the West’s scientism obsession hurts research; how science has too few mystics and too many technicians; “pseudo-delics”; and the serotonin/depression conundrum.

Notable Quotes

“What the paper brings back is that altered states [are] part of the human condition.” -James

“One of the aspects of creativity is allowing us to adapt to a changing environment, to a changing world. So, any potential avenues at all; even if the promise of creativity isn’t guaranteed (it doesn’t need to be guaranteed) – even if there’s the possibility of harnessing or enhancing creativity somewhere; even the mere possibility, I think, makes this area worthy of exploration.” -Sam

On new compounds that take the psychedelic experience out of the substance (sarcastically): “I’m already ready for the next iteration of that, which is: they’re coming up with a substance which you can take which will eliminate the problem of pleasure during sex, …because all of the complications of relationships don’t come from the sexual act, they come from the emotional issues around it. So we can eliminate [the pleasure].” -James

“We’re at the edge of a couple of other possible revolutions. The revolution in mental health that you don’t have to be depressed and that you don’t have to take antidepressants is a major shift; and that it can come from a natural substance that you can grow in your closet; these are huge shifts. Again, what do Indigenous people do when they need a medication? They go out and find where it grows. We are returning to that, but at the level of a large civilization. That’s massive. We’re also taking in what we’ve talked about: a lot of experiences and a lot of parts of consciousness that science has prevented us from looking at for quite a while due to its dominance. And when a culture falls apart, into the cracks come all of these alternatives that have been denied. So that’s where we are, and it’s a wonderful time.” -James

Links

Convergence

Jamesfadiman.com

Psychedelics Today: PT275 – James Fadiman, Ph.D. – Transpersonal Psychology, Microdosing, and Your Symphony of Selves

Researchgate.net: Sam Gandy

Psychedelics Today: PT292 – Sam Gandy – Vital Psychedelic Conversations

Researchgate.net: David Luke

Psychedelics Today: PT296 – Dr. David Luke – Vital Psychedelic Conversations

Sagepub: Psychedelics as potential catalysts of scientific creativity and insight

Sagepub: Psychedelic Agents in Creative Problem-Solving: A Pilot Study (1966)

Futuresciencenews.com: Saudi Arabia starts shift to green fuel production, builds $5B hydrogen plant

What is a pluralistic perspective?

Entangled Life: How Fungi Make Our Worlds, Change Our Minds & Shape Our Futures, by Merlin Sheldrake

Wikipedia.org: Zener cards

Braiding Sweetgrass, by Robin Wall Kimmerer

Wikipedia.org: Hypnagogia

Goodreads.com: August Kekulé quote

On Beyond Zebra! By Dr. Seuss

Sciencedaily.com: No evidence that depression is caused by low serotonin levels, finds comprehensive review

PT352 – HOLOS: Returning to Wholeness Through Nature and Community

In this episode, Joe interviews Alex Enchin & Ian-Michael Hébert, MA; Co-Founders of HOLOS, a company building hospitality wellness centers with a strong focus on community, reconnection to nature, and a return to wholeness. 

HOLOS is currently running retreats in Costa Rica, where they’re in the process of building out their dream wellness center on a very biodiverse 200-acre piece of land complete with 2 km of waterfalls and swimming holes, that, when finished, will have a self-sustaining farm, glamping setup, center for group work, dining hall, and most importantly, 30 lots that are being filled out by various wellness practitioners to round out a surrounding community of support. The idea behind HOLOS is that profound healing can be accomplished in the most beautiful of places with or without psychedelics – that nature’s psychedelic beauty can help visitors return to a wholeness they have likely forgotten. They want to be the place where the biggest psychedelic figureheads visit to relax, commune, and do their own work; to then spread that energy to their individual communities. And, as there isn’t much of an entry point to psychedelic medicine, their next step is to develop a boutique hotel-like wellness center for those who may not yet be ready for a psychedelic experience; to either prepare them for the next step, or to show that nature and community may be all they really need.   

They talk about our need for community and how HOLOS was born; viewing wellness centers and scalability differently; their relationship with Stan Grof and how a canyon can help people experience the perinatal matrices viscerally; consciousness; transpersonal psychology; nondualism; how viewing Mount Denali can be a psychedelic experience; what “returning to wholeness” really means; and Joe’s realization that the vision behind Psychedelics Today is in line with that of HOLOS: to bring back the attitude and energy of Esalen.

Notable Quotes

“We’re a place where people can come home: home to themselves, home to an understanding of our relational nature as human beings, and a place where people can reconnect to nature. …HOLOS was inspired by Stan Grof’s work and the holotropic paradigm, and the returning to wholeness. …The idea is: What is it like when we actually land there, inside of being whole, and recognizing ourselves as a fractal aspect of a greater universal pattern?” -Ian-Michael

“I lived in a condo in Toronto for a bunch of years, and I just don’t believe we’re meant to live like that. Whether I go down to HOLOS for a week or for a month, walking barefoot in the jungle and touching the dirt; it does something. It charges you. It invigorates you. Every time I leave there and come back to North America, I just feel alive and invigorated, and I really believe that’s our natural state.” -Alex 

“People are looking for something to be a part of. …We’re really trying to design and build HOLOS as not just a place that you come once a year or a couple times a year or once every 24 months, but really, something that you can be a part of on an ongoing basis. …We want to have the psychology shift from ‘HOLOS is a place that I go’ to ‘It’s something that I’m a part of.’” -Alex

“There’s an intergenerational reality that we live inside of, of acquired knowledge or knowledge that is transferred over time, and if we don’t start thinking about our cultures that way; where we have the opportunity to grow a body of knowledge or awareness about a particular ecology or particular healing modalities – if we don’t start thinking of that longer-term context of passing down knowledge, then we’re really a short-lived society.” -Ian-Michael

Links

HOLOS.global

Esalen.org

Psychedelics Today: PT293 – Stanislav & Brigitte Grof – The Evolution of Breathwork and The Psychology of the Future

Reuters.com: Canada’s British Columbia to temporarily decriminalize some drug possession to tackle abuse problem

Evaursiny.com: The Perinatal Matrices According to Grof

Spiritplantmedicine.com: Tony Bossis

Benzinga Psychedelics Capital Conference (April 19, 2022)

Erik Davis – High Weirdness: Drugs, Esoterica, and Visionary Experience in the Seventies

Psychedelics Today: PT302 – Dr. Adele Lafrance – Vital Psychedelic Conversations

Dradelelafrance.com: The Love Project

The Institute of Noetic Sciences

Exeter.ac.uk: Dr Peter Sjöstedt-Hughes

Wikipedia.org: Nondualism

Psychedelics Today: PT282 – Rabbi Zac Kamenetz & The Rev. Hunt Priest – Judaism, Christianity, and Embracing Psychedelics

Psychedelics Today: PTSF 35 (with Brian Muraresku)

Psychedelics Today: Aaron Orsini – How LSD Helped Bridge the ASD Neurotypical Divide

The Myth of Normal: Trauma, Illness, and Healing in a Toxic Culture, by Gabor Maté

Whitelions.org

Esalen.org: Michael Murphy Reflects on Esalen’s Past and Future

Track Two: Russian-American Program

Nasa.gov: John Allen

Synergiaranch.com

PT351 – The Trauma In Being Arrested and The Injustice of the Drug War

In this episode, Joe interviews Seth Rosenberg: Washington DC-based mycologist and anti-drug war advocate who worked on DC’s decriminalization Initiative 81.

This episode is a companion piece to the Kole and William Leonard Pickard episodes, as Rosenberg has his own traumatic arrest story. He believes that it was his arrogance in posting pictures online about how to grow mushrooms that initially flagged him, and then an internet purchase of legal mescaline-containing plants that somehow led to 11 armed SWAT agents knocking on his door while he was cooking for his family. He tells his story, detailing the financial and emotional impact created from being arrested for legal activity, and asks some powerful questions: Why did they choose to arrest him in this way? With such an obvious case of injustice, why did nobody reach out and help him? And with charges later considerably lessened, are arrests like this done just to scare brazen people into fearful compliance?  

They also talk about the beginnings of (and racism in) the drug war; the fundamental problem with the “grow, gather, give” concept of the decrim movement; Dr. Carl Hart; why biotech companies racing to create new compounds likely won’t last; IV ketamine and concerns over ketamine being overhyped; the factor of spirituality in the psychedelic experience (and psychiatry’s disinterest in it); the fluidity of morality over time; the unintended segregation within the psychedelic space; and the very scary reality that no one can ever really hide anything from the government.

Notable Quotes

“My arrest with 11 people coming in for a mailed package of cactus, with machine guns, with a child in the house, could have been a traffic stop. I could have been called downstairs to sign for the package. There were a number of options that could have happened, but instead, they chose to wait for my daughter to be there and come in with machine guns.”

“The thing that bothers me the most about the decrim movement …is the ‘grow, gather, give’ model, which sounds great and it sounds very community-based, but the truth is: the grower, the gatherer, and the giver are one person. Everyone else is taking. And that’s a very risky person to be, as I found out. …There’s this idea that we’re all going to get together and do this thing, but once you follow the ideas out more logically, they don’t really seem to carry water.” 

“I don’t think anybody has any idea what being arrested is until you have been arrested. I mean, I get emotional just thinking about it. It’s incredibly traumatic. You can think, ‘Oh yeah, I can deal with that,’ and maybe if what happened is you got arrested at a DUI stop and it’s just a big hassle, fine – that’s one thing. But whatever you think your reaction is going to be when 11 SWAT guys bust in your door; you have absolutely no idea.”

“They know everything. They are paying attention to everything. They have seen all of your Facebook posts, they have seen all of your Reddit posts. If you are posting about drug use, they already know who you are. …They knew more than I ever imagined that they would know. They know everything. There is no privacy. Once they have decided you are a subject of interest; everything, everything, everything is in the open. That’s it. It’s done. And it’s in the open basically forever.”

Links

Districtpsychedelic.com

Linkedin

Ballotpedia.org: Washington, D.C., Initiative 81, Entheogenic Plants and Fungus Measure (2020)

Psychedelics Today: PT338 – Melissa Lavasani – The Power of Storytelling, The Preservation of Peyote, and “How to Change Your Mind”

Psychedelics Today: PT319 – Kole – Activism and Trust: A Cautionary Tale From Someone Who Got Caught

Psychedelics Today: PT311 – William Leonard Pickard – LSD, Fentanyl, Prison, and the Greatest Gift of All: The Natural Mind

The Mycological Association of Washington

Hopkinspsychedelic.org: Albert Garcia-Romeu, Ph.D.

This Is Your Mind on Plants, by Michael Pollan

Troutsnotes.com

Fieldtriphealth.com

Drug Use for Grown-Ups: Chasing Liberty in the Land of Fear, by Dr. Carl L. Hart

Psychedelics Today: PT236 – Dr. Carl Hart – Drugs: Honesty, Responsibility, and Logic

Chasing the Scream: The Inspiration for the Feature Film the United States vs. Billie Holiday, by Johann Hari

Psychedelics Today: Psychedelics and Religious Liberty in the United States

Wikipedia.org: Pegasus spyware

PT350 – Psilocybin and Accessing the “Off” Switch For Nociplastic Pain

In this episode, David interviews Jim Gilligan: Interim CEO and Chief Scientific Officer of Tryp Therapeutics, a biotech company researching new compounds and delivery mechanisms for the treatment of eating disorders and nociplastic pain (fibromyalgia, phantom limb syndrome, complex regional pain syndrome). 

Gilligan discusses how nociplastic pain (and likely, eating disorders) seem to be caused by a switch staying on inside the patient’s brain, and wonders why psilocybin seems to be the key to accessing that switch. Tryp wants to understand this better, and is currently running exploratory studies with oral psilocybin to collect enough data to move forward with their next step; the development (and bringing to market) of TRP-8803: a novel delivery mechanism for psilocybin that he believes will allow clinicians to know when the psychedelic experience will kick in, control how long it lasts, end the experience if the patient needs it, or extend it if they believe the patient will benefit. He views the substance and experience from a different angle, considering the set and setting for the molecule itself: How can research studies be set up to give the molecule the absolute best chance to prove that it works on its own?

He also talks about how the neural network seems to hold onto memories (whether they’re accessible or not); the therapy factor and ways to manage long-term efficacy; Prader-Willi syndrome and hypothalamic obesity; the unfortunate necessity of patents to the companies spending millions trying to bring a drug to market; and why, in the newly-risky world of psychedelic stocks, he believes Tryp is a safe bet.

Notable Quotes

“There is an initial benefit that you derive from the administration of a psychedelic, but how do you maintain that durability? Even if you have been successful in changing the switch, I think the therapist is going to be important to make sure that switch stays turned off.”

“They see this even in patients with Alzheimer’s; that they may not remember their children’s names, but you put on a Frank Sinatra song and they know all the lyrics. So that neural network is still there. We know that that switch is in there. We know that there’s something that has to be changed. It’s: How do you get to it? And that comes back to the power of the psychedelics and knowing that it does have an effect on neural networks, and how do you create the environment, how do you create a situation where you can capitalize on that?”

“I’m really passionate about this. I think that [from] my nearly forty years of working in this field, I just see tremendous potential here. And it’s up to people like myself and others in the industry to deliver that potential to the patients.”

Links

Tryptherapeutics.com

Tryptherapeutics.com: Tryp Therapeutics Announces $2,000,000 Financing and Changes in Management, Board of Directors

Psychedelics Today: PT283 – Greg McKee – Nociplastic Pain and Psychedelics

Medicine.umich.edu: Daniel Clauw, M.D.

Psychedelics Today: PT245 – Robin Carhart-Harris – Psychedelics, Entropy, and Plasticity

Mayoclinic.org: Prader-Willi syndrome

Med.ufl.edu: Jennifer L Miller, M.D.

Pubmed: Hypothalamic obesity: causes, consequences, treatment

Fluencetraining.com